Journal article
A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients
J Cursons, F Souza-Fonseca-Guimaraes, M Foroutan, A Anderson, F Hollande, S Hediyeh-Zadeh, A Behren, ND Huntington, MJ Davis
Cancer Immunology Research | AMER ASSOC CANCER RESEARCH | Published : 2019
Abstract
Natural killer (NK) cell activity is essential for initiating (TCGA), we show that patients with metastatic cutaneous antitumor responses and may be linked to immunotherapy melanoma have an improved survival rate if their tumor success. NK cells and other innate immune components shows evidence of NK cell infiltration. Furthermore, these could be exploitable for cancer treatment, which drives the survival effects are enhanced in tumors that show higher need for tools and methods that identify therapeutic ave-expression of genes that encode NK cell stimuli such as the nues. Here, we extend our gene-set scoring method singscore cytokine IL15. Using this signature, we then examine tran-to inves..
View full abstractGrants
Awarded by Cancer Research Institute
Funding Acknowledgements
This work is supported in part by project grants from the National Health and Medical Research Council (NHMRC) of Australia (#1147528 to J. Cursons; #1128609 to M. J. Davis; #1124784, #1066770, #1057812, and #1124907 to N. D. Huntington; #1164081 to F. Hollande; and #1140406 to F. Souza-Fonseca-Guimaraes). F. Souza-Fonseca-Guimaraes was supported by NHMRC Early Career Fellowship (1088703), National Breast Cancer Foundation (NBCF) Fellowship (PF-15-008), and grant #1120725 awarded through the Priority-driven Collaborative Cancer Research Scheme and funded by Cure Cancer Australia with the assistance of Cancer Australia. A. Behren is the recipient of a Fellowship from the Victorian Government Department of Health and Human Services acting through the Victorian Cancer Agency. N. D. Huntington is an NHMRC CDF2 Fellow (1124788), a recipient of a Melanoma Research Grant from the Harry J Lloyd Charitable Trust, Melanoma Research Alliance Young Investigator Award, and a CLIP grant from Cancer Research Institute. M. J. Davis was supported by NBCF Career Development Fellowship ECF-14-043 and is the recipient of the Betty Smyth Centenary Fellowship in Bioinformatics. This study was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme. Results published here are based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/.